One‐way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential
Identifieur interne : 000614 ( Main/Exploration ); précédent : 000613; suivant : 000615One‐way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential
Auteurs : Jason S. Long [Royaume-Uni] ; Camilla T. Benfield [Royaume-Uni] ; Wendy S. Barclay [Royaume-Uni]Source :
- BioEssays [ 0265-9247 ] ; 2015-02.
Abstract
We hypothesise that some influenza virus adaptations to poultry may explain why the barrier for human‐to‐human transmission is not easily overcome once the virus has crossed from wild birds to chickens. Since the cluster of human infections with H5N1 influenza in Hong Kong in 1997, chickens have been recognized as the major source of avian influenza virus infection in humans. Although often severe, these infections have been limited in their subsequent human‐to‐human transmission, and the feared H5N1 pandemic has not yet occurred. Here we examine virus adaptations selected for during replication in chickens and other gallinaceous poultry. These include altered receptor binding and increased pH of fusion of the haemagglutinin as well as stalk deletions of the neuraminidase protein. This knowledge could aid the delivery of vaccines and increase our ability to prioritize research efforts on those viruses from the diverse array of avian influenza viruses that have greatest human pandemic potential. Also watch the Video Abstract.
Adaptation of influenza viruses to poultry results in altered receptor binding, increased pH of fusion of the haemagglutinin and neuraminidase stalk deletions, which may compromise human‐to‐human transmission. We suggest a trade‐off exists between high pathogenicity and transmissibility since HA stability may confer greater susceptibility to control by IFITM‐3.
Url:
DOI: 10.1002/bies.201400133
Affiliations:
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Long</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College London, Department of Medicine, Section of Virology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Benfield, Camilla T" sort="Benfield, Camilla T" uniqKey="Benfield C" first="Camilla T." last="Benfield">Camilla T. Benfield</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Veterinary College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S." last="Barclay">Wendy S. 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Since the cluster of human infections with H5N1 influenza in Hong Kong in 1997, chickens have been recognized as the major source of avian influenza virus infection in humans. Although often severe, these infections have been limited in their subsequent human‐to‐human transmission, and the feared H5N1 pandemic has not yet occurred. Here we examine virus adaptations selected for during replication in chickens and other gallinaceous poultry. These include altered receptor binding and increased pH of fusion of the haemagglutinin as well as stalk deletions of the neuraminidase protein. This knowledge could aid the delivery of vaccines and increase our ability to prioritize research efforts on those viruses from the diverse array of avian influenza viruses that have greatest human pandemic potential. Also watch the Video Abstract.</div><div type="abstract">Adaptation of influenza viruses to poultry results in altered receptor binding, increased pH of fusion of the haemagglutinin and neuraminidase stalk deletions, which may compromise human‐to‐human transmission. We suggest a trade‐off exists between high pathogenicity and transmissibility since HA stability may confer greater susceptibility to control by IFITM‐3.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Long, Jason S" sort="Long, Jason S" uniqKey="Long J" first="Jason S." last="Long">Jason S. Long</name></region><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S." last="Barclay">Wendy S. 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